Bartonella seropositivity in children with Henoch-Schonlein purpura

نویسندگان

  • Joan L Robinson
  • Donald W Spady
  • Errol Prasad
  • Dorothy McColl
  • Harvey Artsob
چکیده

BACKGROUND An association between Henoch-Schonlein purpura (HSP) and seropositivity for Bartonella henselae (BH) has been described. The objective of this study was to see if such an association exists in northern Alberta. METHODS Immunofluorescent antibody testing utilizing an antigen prepared from B. henselae was undertaken on sera from six children with current HSP, 22 children with remote HSP, and 28 controls that were matched for age. Blood from the six children with current HSP was analysed by polymerase chain reaction (PCR) assay with primers derived from the citrate synthase (gltA) gene for the detection of Bartonella DNA. RESULTS The seropositivity rate for BH was 61% in cases versus 21% in controls (p < 0.03). The PCR assay was negative in all six current cases. CONCLUSION There is an increased seropositivity rate for BH in children with HSP. However, it is not clear if infection with B. henselae or a related Bartonella species can result in HSP, or if the increased seropositivity is from non-specific or cross-reacting antibodies.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Immune thrombocytopenic purpura as a complication of Bartonella henselae infection.

Immune thrombocytopenic purpura is an infrequent yet well-recognized complication of viral infections, such as mumps, rubella, varicella, cytomegalovirus, parvovirus and infectious monunucleosis by Epstein-Barr virus. Some recent studies have described a possible association between Henoch-Schonlein purpura, a non-thrombocytopenic purpura, and seropositivity for Bartonella henselae, but in the ...

متن کامل

A Case Report of Hodgkin's lymphoma with Early Manifestation of Henoch-Schonlein Purpura in a Child

Hodgkin's lymphoma is one of the most common types of lymphoma among children, usually characterized by persistent head and neck adenopathies that are unresponsive to antibiotic treatment. In rare cases, the primary manifestation of this malignancy includes paraneoplastic, immunological, and vasculitic syndromes in children. Here, we introduce a 13-year-old boy, and Hodgkin's lymphoma was initi...

متن کامل

Itching Papules in a child; Scabies or Henoch Schonlein Purpura?

Introduction: Henoch schonlein purpura (HSP) is a self-limited systemic disease with multiorgan involvement. While cutaneous involvement may wary, presenting as itching papules is not a common manifestation. In this report we discuss a case of HSP which was presented solely with itching papules; mistaken for scabies. Case presentation: A 7 year old boy presented with itchy palpable papules with...

متن کامل

HENOCH-SCHONLEIN PURPURA IN CHILDREN: OUR EXPERIENCE WITH 165 CASES FROM SOUTHERN IRAN

During a 6 year period from September 1992 to September 1998, 165 children with a final diagnosis of Henoch-Schonlein purpura (HSP) were managed and followed in our center. There were 87 (52%) boys and 78 (48%) girls, with age ranges of 1-16 years and mean age of 7.8 years. Forty-one percent of the patients had evidence of preceding upper respiratory tract infection (URI). The main clinica...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • BMC Infectious Diseases

دوره 5  شماره 

صفحات  -

تاریخ انتشار 2005